S. Sinn, J. Krämer, F. Biedermann, Chem. Commun. 2020,  56, 6620-6623.

DOI: 10.1039/D0CC01841D



A simple change has important consequences: The guest-displacement assay (GDA) is introduced which allows for binding affinity determinations of supramolecular complexes with spectroscopically silent hosts and guests. GDA is complementary to indicator-displacement assay for affinity measurements with soluble components, but is superior for insoluble of for weakly binding guests.