The creation of artificial receptors remains an open challenge in supramolecular chemistry. In particular, the detection of small biomolecules in aqueous or complex biological media by supramolecular chemosensors proved difficult. We have developed a remarkably facile and versatile biomimetic strategy for the design of high-affinity artificial receptors by exploiting a combination of specific analyte-host interactions and the powerful, non-classical hydrophobic effect as driving forces for binding. Current developments include the monitoring of dynamic processes, e.g. of enzymatic reactions, and the extension of the sensors to applications in living cells.
Photophysical characterisation of supramolecular and self-assembled systems (Circular Dichroism spectroscopy with FDCD capabilities & Emission spectroscopy)
Calorimetric binding studies (Isothermal Titration Calorimetry, ITC)
Synthesis of molecular hosts and dyes (automated flash chromatography & photoreactor)