We studied the interactions between [2.2]paracyclophanes (PCPs) and CB8, revealing ultra-high binding affinities in water. The modifiability, solubility, and fluorescence of cationic PCPs make them ideal guests for CB8-based assays and materials.

CB7-chemosensor-loaded polymersomes with a pDMA corona detect bioactive molecules in biofluids and are used for imaging in living cells. The semipermeable membrane acts as a molecular sieve, shielding chemosensors from protein-mediated deactivation.

Macrocyclic hosts like cucurbit[8]uril (CB8) significantly affect chemical reactions with encapsulated guests. This study shows that CB8 completely reverses the stereoselectivity of intramolecular [2+2] photo-cycloaddition reactions.

CB7 controls the photolysis pathway of aryl azides in water, leading to carboline derivatives with long-lived room-temperature phosphorescence. This demonstrates CB7's potential in modulating photolysis and creating phosphorescent materials.

We introduce responsive organosilica nanoparticles (NPs) using nucleic acid interactions and sol-gel chemistry. These programmable NPs respond to physical and biological stimuli, offering functionalities for drug delivery and diagnostic applications.

Our study explores the thermodynamics of host-guest binding in water for CB7, CB8 and β-CD using ITC experiments and MD simulations. We report negative heat capacity changes (ΔCp,b) across all systems, indicating strong solvation effects.

Using nucleic acid interactions and sol-gel chemistry, we created smart organosilica NPs that respond to multiple stimuli. These NPs hold promise for multifaceted biomedical applications.

We developed a CB7-NBD conjugate for label-free fluorescence chemosensing, addressing IDA limitations. This chemosensor detects various analytes in live cells and works with fluorescence imaging, FACS, and microplate spectrometry.

We introduce a cucurbit[7]uril-based electrochemical chemosensor for detecting the muscle relaxant pancuronium bromide in human urine. Our design eliminates the need for electrode immobilization and works with commercial screen-printed electrodes.

This study uses aqueous two-phase extraction to obtain highly purified left- and right-handed single-wall carbon nanotube (SWCNT) enantiomers. Surfactant conditions are optimized, and the separation mechanisms are examined.

A molecular engineering approach introduces a cucurbit[8]uril-based rotaxane chemosensor for detecting biomarker tryptophan in human blood serum and urine. This chemosensor enables high-throughput screening, label-free enzymatic reaction monitoring.

A new multifunctional aryl azide is reported for peptoid synthesis, providing mild thiol protection and further functionalization via copper-catalyzed cycloaddition for materials chemistry.

A novel cucurbit[7]uril-dye conjugate allows distinguishing 14 bioorganic analytes through salt-induced adaptation, offering a low-effort alternative to array-based chemosensing methods.

A novel chemiluminescent assay with cucurbit[8]uril enhances detection sensitivity for drugs in human samples and demonstrates the potential for chemiluminescence resonance energy transfer.

Thermodynamic binding parameters (ΔG, ΔH, TΔS) for CB7 and CB8-complexes show solvation energies as crucial factors, not electrostatic interactions or London dispersion forces.

Dive into our comprehensive review assessing the promises and hurdles of synthetic probes, chemosensors, and nanosensors, illuminating their potential for rapid, cost-effective diagnostics and biofluid analysis.

Discover our versatile method for simultaneous assessment of complex formation and dissociation rates in host-guest systems, paving the way for streamlined kinetic and thermodynamic characterization.

Through a novel design strategy, this study presents ZARs: synthetic artificial receptors based in microporous zeolites that can sense serotonin and dopamine in aqueous media with an unmatched affinity and selectivity.

FDCD proves to be an effective tool for supramolecular systems, showcasing high sensitivity in chiral analyte detection and offering an advantageous combination with ECD for an enriched chiroptical characterization.

This research explores the patterned immobilization of CBn into microarrays as supramolecular chemosensors, demonstrating increased sensitivity and efficiency in small molecule analyte detection and showcasing a path for multicomponent sensing.

Remarkably, the small molecule HINA exhibits green fluorescence and pH sensitivity, promising potential in fluorescent-based cysteine detection and presenting an intriguing model for advancing photophysics research.

Using the NMR-based GEST approach, this study quantifies dissociation rates and activation energy in host-guest systems, highlighting the role of monovalent cations as 'supramolecular lids' in influencing the binding and unbinding kinetics.

Introducing covalent cucurbit[7]uril–indicator dye conjugates, this research shows their stability in saline conditions and their efficacy in detecting Parkinson's drug amantadine in biofluids.

Three novel time-resolved methods are introduced in this research for determining kinetic rate constants in supramolecular systems, allowing for comprehensive analysis of host-guest interactions with spectroscopically silent or insoluble guests.

FARMA, a novel, label-free method, is presented, enabling real-time and high-sensitivity spatiotemporal monitoring of membrane translocation of organic compounds.

Presenting the guest-displacement assay (GDA), this research improves the determination of binding affinities for supramolecular complexes, proving especially effective for spectroscopically silent, insoluble, or weakly binding guests.

This research reveals that achiral chromophoric hosts can produce distinctive Circular Dichroism (CD) spectra when interacting with chiral compounds, offering new opportunities for identifying analytes and monitoring reactions.

This study uncovers two contrasting release mechanisms of two organic guests from cucurbit[7]uril (CB7), revealing previously unseen mechanistic aspects and prompting broader kinetic investigations of host-guest systems.

This study uncovers two contrasting release mechanisms of two organic guests from cucurbit[7]uril (CB7), revealing previously unseen mechanistic aspects and prompting broader kinetic investigations of host-guest systems.

Peptide membrane transport can now be monitored in real time using a novel fluorescence-based method. Validated with various cell-penetrating peptides, the technique paves the way for an enhanced understanding of membrane transport mechanisms.

High binding constants of 19 inorganic cations with the cucurbit[n]uril homologues (CBn, n = 5, 6, 7, 8) in water were determined and the far-reaching consequences and interferences of the high affinities (millimolar to micromolar) are discussed.

A novel supramolecular indicator displacement assay (IDA) is introduced, employing cucurbit[8]uril as the host and a high-affinity paracyclophane dye, enabling the emission-based detection of Alzheimer's drug memantine in serum.

This book chapter provides a deep dive into water-compatible host systems, covering acyclic structures, molecular tweezers, and a spectrum of macrocyclic receptors, with additional practical guidelines for host selection.

This book chapter delivers a detailed exploration of ion receptors, discussing their potential applications and their binding modes, and dives into the nuances of cation, anion, and zwitterion receptors, closing with future challenges in the field.

Through the study of noble gases' binding with a macrocyclic receptor in water, it's revealed that differential cavitation energies drive host-guest binding, shedding light on gas-storage materials and biological receptors.

This review article presents an in-depth examination of cucurbit[n]urils (CBn), emphasizing their high affinity for biologically relevant analytes and their potential in creating robust chemosensors for bio-monitoring and imaging applications.

This essay provides an opinion piece on the role of 'emptiness' in molecular systems. Investigations on hydrogels, metal-organic frameworks, and molecular hosts unveil novel perspectives on molecular recognition and porous materials'...

The creation of virus-like particles (VLPs) using luminescent Pt(II) complex amphiphiles demonstrates the potential of custom supramolecular systems in controlling the assembly of biological structures.

This research provides a detailed investigation into the binding dynamics of various polymeric guests that form ternary complexes with cucurbit[8]uril, demonstrating the flexibility in designing host-guest systems for a broad range of applications.

In this review, a thorough dissection of supramolecular assemblies in aqueous contexts is conducted, discussing a broad spectrum of self-assembling components and design strategies.

The development of a reactive phosphorescent Pt-based probe led to an emission-switch-on chemosensor capable of differentiating aza-heterocyclic drugs and toxins in water.

The use of Cucurbit[n]urils (CBn) as artificial receptors for steroids has been explored, revealing remarkable binding affinities and selectivities. This opens opportunities for enhanced drug delivery, enzyme assays, and differential sensing.

A comprehensive examination of the binding strength in noncovalent supramolecular systems is provided, comparing various measurement strategies and their merits and limitations, as well as systematically exploring the different interaction types.

A ratiometric chemosensor for potassium, employing phosphorescent dinuclear cyclometalated PtII complexes, has been designed. Notable emission changes upon cation binding indicate potential for ratiometric sensing applications.