Alternativtext für das Icon

Discover Our Published Papers

Alternativtext für das Bild
Cover of our Chemical Reviews article
Joana Krämer et al. 07.01.2022

Explore our in-depth review of chemosensors, nanosensors and molecular probes, and their ability to identify metabolites, drugs, and toxins in biofluids.

Cover of our Advanced Materials article
Laura M. Grimm et al. 27.09.2021

Explore our novel zeolite-based artificial receptors that bind the neurotransmitters serotonin & dopamine with high affinity and selectivity in biofluids.

First Page of our Nature Communications article
Joana Krämer et al. 31.01.2023

Discover a cucurbit[8]uril-based rotaxane for tryptophan sensing in biofluids, enabling enzymatic reaction monitoring & chirality analysis.

First page of our ACS Sensors article
Nilima M. Kumar et al. 27.07.2022

Explore a chemiluminescence-based assay that enables low-micromolar drug detection, improves dioxetane emission QY in water & allows herbicide sensing.

Cover of our Chemical Communications article
Sinn et al. 01.05.2020

Check out the innovative GDA method, enabling precise binding affinity determinations in spectroscopically silent host-guest pairs.

First page of our JACS article
Changming Hu et al. 18.07.2022

Delve into a data-driven approach utilizing a salt-adaptive cucurbit[7]uril system for distinguishing bioorganic analytes in biofluids like urine and serum.

Cover of our Chemical Communications article
Prabodh et al. 25.02.2020

Discover the potential of achiral chromophoric hosts in identifying chiral substances and monitoring their reactions by Circular Dichroism (CD) spectroscopy.

Cover of our Chemical Communications article
Prabodh et al. 15.07.2020

Check out the label-free time-resolved methods providing kinetic insights into host-guest complexation and decomplexation dynamics.

Cover of our Chemical Science article
Shusterman-Krush et al. 08.12.2020

Discover how GEST, an NMR-based method, can be used for quantifying kinetic parameters of fast-dissociating host-guest systems.

Cover of our ACS Applied Nano Materials article
Zhong et al. 13.03.2021

Explore the advancement of supramolecular chemosensors through patterned immobilization of cucurbit[n]urils into multiplexed microarrays.

Cover of our Chemicals Science article
Hu et al. 01.06.2020

Explore how covalent cucurbit[7]uril-dye conjugates overcome the limitations of non-covalent chemosensors, offering a tailored analyte-selectivity.

Cover of our Chemicals Science article
Sinn et al. 04.06.2019

Discover the first implementation of supramolecular IDA in blood serum, utilizing an ultra-high affinity dye and cucurbit[8]uril for Alzheimer's drug detection.

P. Picchetti et al. Responsive Nucleic Acid-Based Organosilica Nanoparticles, J. Am. Chem. Soc. 2023, XXX XXX 21.09.2023

Using nucleic acid interactions and sol-gel chemistry, we created smart organosilica NPs that respond to multiple stimuli. These NPs hold promise for multifaceted biomedical applications.

N. M. Kumar, P. Gruhs, A.Casini, F. Biedermann, G. M. Alcántar, P. Picchetti, Electrochemical Detection of Drugs via a Supramolecular Cucurbit[7]uril-Based Indicator Displacement Assay, ACS Sensors, 2023, 8, 7, 2525–2532 20.06.2023

We introduce a cucurbit[7]uril-based electrochemical chemosensor for detecting the muscle relaxant pancuronium bromide in human urine. Our design eliminates the need for electrode immobilization and works with commercial screen-printed electrodes.

H. Li, C. M. Sims, R. Kang, F. Biedermann, J. A. Fagan, B. S. Flavel, Isolation of the (6,5) single-wall carbon nanotube enantiomers by surfactant-assisted aqueous two-phase extraction. Carbon 2023, 204, 475. 01.02.2023

This study uses aqueous two-phase extraction to obtain highly purified left- and right-handed single-wall carbon nanotube (SWCNT) enantiomers. Surfactant conditions are optimized, and the separation mechanisms are examined.

J. Krämer, L. M. Grimm, C. Zhong, M. Hirtz, F. Biedermann, A supramolecular cucurbit[8]uril-based rotaxane chemosensor for the optical tryptophan detection in human serum and urine, Nat. Commun., 2023, 14, 518. 31.01.2023

A molecular engineering approach introduces a cucurbit[8]uril-based rotaxane chemosensor for detecting biomarker tryptophan in human blood serum and urine. This chemosensor enables high-throughput screening, label-free enzymatic reaction monitoring.

X. Qiu, J. Brückel, C. Zippel, M. Nieger, F. Biedermann, S. Bräse, Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group. RSC Advances 2023, 13, 2483. 17.01.2023

A new multifunctional aryl azide is reported for peptoid synthesis, providing mild thiol protection and further functionalization via copper-catalyzed cycloaddition for materials chemistry.

C. Hu et al., Further Dimensions for Sensing in Biofluids: Distinguishing Bioorganic Analytes by the Salt-induced Adaptation of a Supramolecular Chemosensor, J. Am. Chem. Soc. 2022, 144, 13084-13095. 18.07.2022

A novel cucurbit[7]uril-dye conjugate allows distinguishing 14 bioorganic analytes through salt-induced adaptation, offering a low-effort alternative to array-based chemosensing methods.

N. M. Kumar, P. Picchetti, C. Hu, L. M. Grimm, F. Biedermann, Chemiluminescent Cucurbit[n]uril-Based Chemosensor for the Detection of Drugs in Biofluids, ACS Sensors 2022, 7, 2312-2319. 17.07.2022

A novel chemiluminescent assay with cucurbit[8]uril enhances detection sensitivity for drugs in human samples and demonstrates the potential for chemiluminescence resonance energy transfer.

L. M. Grimm, S. Spicher, B. Tkachenko, P. R. Schreiner, S. Grimme, F. Biedermann, The Role of Packing, Dispersion, Electrostatics, and Solvation in High-Affinity Complexes of Cucurbit[n]urils with Uncharged Polar Guests, Chem. Eur. J., 2022, 28. 25.02.2022

Thermodynamic binding parameters (ΔG, ΔH, TΔS) for CB7 and CB8-complexes show solvation energies as crucial factors, not electrostatic interactions or London dispersion forces.

J. Krämer, R. Kang, L. M. Grimm, L. De Cola, P. Picchetti, F. Biedermann, Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids,Chem. Rev. 2022, 122, 3459. 07.01.2022

Dive into our comprehensive review assessing the promises and hurdles of synthetic probes, chemosensors, and nanosensors, illuminating their potential for rapid, cost-effective diagnostics and biofluid analysis.

Z. Miskolczy, M. Megyesi, S. Sinn, F. Biedermann, L. Biczok, Simultaneous analyte indicator binding assay (SBA) for the monitoring of reversible host-guest complexation kinetics, Chem. Commun. 2021, 57, 12663. 08.10.2021

Discover our versatile method for simultaneous assessment of complex formation and dissociation rates in host-guest systems, paving the way for streamlined kinetic and thermodynamic characterization.

L. Grimm et al., Fluorescent nanozeolite receptors for the highly selective and sensitive detection of neurotransmitters in water and biofluids, Adv. Mater. 2021, 2104614. 27.09.2021

Through a novel design strategy, this study presents ZARs: synthetic artificial receptors based in microporous zeolites that can sense serotonin and dopamine in aqueous media with an unmatched affinity and selectivity.

A. Prabodh, Y. Wang, S. Sinn, P. Albertini, E. Spuling, L.-P. Yang, W. Jiang, S. Bräse, F. Biedermann, Fluorescence Detected Circular Dichroism (FDCD) for Supramolecular Host-Guest Complexes, Chem. Sci., 2021, 12, 9420. 09.06.2021

FDCD proves to be an effective tool for supramolecular systems, showcasing high sensitivity in chiral analyte detection and offering an advantageous combination with ECD for an enriched chiroptical characterization.

C. Zhong, C. Hu, R. Kumar, V. Trouillet, F. Biedermann, M. Hirtz, Cucurbit[n]uril-Immobilized Sensor Arrays for Indicator-Displacement Assays of Small Bioactive Metabolites. ACS Appl. Nano Mater., 2021, 4, 4676. 13.03.2021

This research explores the patterned immobilization of CBn into microarrays as supramolecular chemosensors, demonstrating increased sensitivity and efficiency in small molecule analyte detection and showcasing a path for multicomponent sensing.

R. Kang, L. Talamini, E. D'Este, B. M. Estevão, L. De Cola, W. Klopper, F. Biedermann, Discovery of a size-record breaking green-emissive fluorophore: small, smaller, HINA, Chem. Sci. 2021, 12, 1392. 01.01.2021

Remarkably, the small molecule HINA exhibits green fluorescence and pH sensitivity, promising potential in fluorescent-based cysteine detection and presenting an intriguing model for advancing photophysics research.

R. Shusterman-Krush, L. Grimm, L. Avram, F. Biedermann, A. Bar-Shir, Elucidating dissociation activation energies in host–guest assemblies featuring fast exchange dynamics, Chem. Sci. 2021, 12, 865. 08.12.2020

Using the NMR-based GEST approach, this study quantifies dissociation rates and activation energy in host-guest systems, highlighting the role of monovalent cations as 'supramolecular lids' in influencing the binding and unbinding kinetics.

C. Hu, L. Grimm, A. Prabodh, A. Baksi, A. Siennicka, P. A. Levkin, M. M. Kappes, F. Biedermann, Covalent Cucurbit[7]uril-Dye Conjugates for Sensing in Aqueous Saline Media and Biofluids, Chem. Sci., 2020, 11, 11142. 22.09.2020

Introducing covalent cucurbit[7]uril–indicator dye conjugates, this research shows their stability in saline conditions and their efficacy in detecting Parkinson's drug amantadine in biofluids.

A. Prabodh, S. Sinn, L. Grimm, Z. Miskolczy, M. Megyesi, L. Biczók, S. Bräse, F. Biedermann, Teaching indicators to unravel the kinetic features of host–guest inclusion complexes Chem. Commun., 2020, 56, 12327. 15.07.2020

Three novel time-resolved methods are introduced in this research for determining kinetic rate constants in supramolecular systems, allowing for comprehensive analysis of host-guest interactions with spectroscopically silent or insoluble guests.

F. Biedermann, G. Ghale, A. Hennig, W. M. Nau, Fluorescent Artificial Receptor-Based Mem-brane Assay (FARMA) for Spatiotemporally Resolved Monitoring of Biomembrane Permeability, Commun. Biol., 2020, 3, 383 . 15.07.2020

FARMA, a novel, label-free method, is presented, enabling real-time and high-sensitivity spatiotemporal monitoring of membrane translocation of organic compounds.

S. Sinn, J. Krämer, F. Biedermann, Teaching Old Indicators Even More Tricks: Binding Affinity Measurements with the Guest-Displacement Method (GDA), Chem. Commun., 2020, 56, 6620. 01.05.2020

Presenting the guest-displacement assay (GDA), this research improves the determination of binding affinities for supramolecular complexes, proving especially effective for spectroscopically silent, insoluble, or weakly binding guests.

A. Prabodh et al., Chirality sensing of terpenes, steroids, amino acids, peptides and drugs with acyclic cucurbit[n]urils and molecular tweezers, Chem. Commun., 2020, 56, 4652. 20.02.2020

This research reveals that achiral chromophoric hosts can produce distinctive Circular Dichroism (CD) spectra when interacting with chiral compounds, offering new opportunities for identifying analytes and monitoring reactions.

Z. Miskolczy, M. Megyesi, L. Biczók, A. Prabodh, F: Biedermann, Mechanism of cation-induced guest release from cucurbit[7]uril, Chem: Eur. J., 2020 , 26, 7433. 13.01.2020

This study uncovers two contrasting release mechanisms of two organic guests from cucurbit[7]uril (CB7), revealing previously unseen mechanistic aspects and prompting broader kinetic investigations of host-guest systems.

Z. Miskolczy, M. Megyesi, L. Biczók, A. Prabodh, F: Biedermann, Mechanism of cation-induced guest release from cucurbit[7]uril, Chem: Eur. J., 2020 , 26, 7433. 13.01.2020

This study uncovers two contrasting release mechanisms of two organic guests from cucurbit[7]uril (CB7), revealing previously unseen mechanistic aspects and prompting broader kinetic investigations of host-guest systems.

A. Barba-Bon, Y.-C. Pan, F. Biedermann, D.-S. Guo, W. M. Nau, A. Hennig, Fluorescence Monitoring of Peptide Transport Pathways into Large and Giant Vesicles by Supramolecular Host–Dye Reporter Pairs, J. Am. Chem. Soc. 2019, 141, 20137. 18.11.2019

Peptide membrane transport can now be monitored in real time using a novel fluorescence-based method. Validated with various cell-penetrating peptides, the technique paves the way for an enhanced understanding of membrane transport mechanisms.

S. Zhang, L. Grimm, Z. Miskolczy, L. Biczók, F. Biedermann, W. M. Nau, Binding affinities of cucurbit[n]urils with cations, Chem. Commun. 2019, 55, 14131. 23.10.2019

High binding constants of 19 inorganic cations with the cucurbit[n]uril homologues (CBn, n = 5, 6, 7, 8) in water were determined and the far-reaching consequences and interferences of the high affinities (millimolar to micromolar) are discussed.

S. Sinn, E. Spuling, S. Bräse, F. Biedermann, Rational design and implementation of a cucurbit[8]uril-based indicator-displacement assay for application in blood serum. Chem. Sci. 2019, 10, 6584. 04.06.2019

A novel supramolecular indicator displacement assay (IDA) is introduced, employing cucurbit[8]uril as the host and a high-affinity paracyclophane dye, enabling the emission-based detection of Alzheimer's drug memantine in serum.

F. Biedermann, Water-Compatible Host Systems. Supramolecular Chemistry in Water, (Ed.: S. Kubik), Wiley-VCH, Weinheim, 2019, pp 35-77. 01.05.2019

This book chapter provides a deep dive into water-compatible host systems, covering acyclic structures, molecular tweezers, and a spectrum of macrocyclic receptors, with additional practical guidelines for host selection.

L. Leoni, A. D. Cort, F. Biedermann, S. Kubik, Ion Receptors. Supramolecular Chemistry in Water, (Ed.: S. Kubik), Wiley-VCH, Weinheim, 2019, pp 193-247. 01.05.2019

This book chapter delivers a detailed exploration of ion receptors, discussing their potential applications and their binding modes, and dives into the nuances of cation, anion, and zwitterion receptors, closing with future challenges in the field.

S. He, F. Biedermann, N. Vankova, L. Zhechkov, T. Heine, R. E. Hoffman, A. De Simone, T. T. Duignan, W. M. Nau, Cavitation energies can outperform dispersion interactions. Nat. Chem. 2018, 10, 1252. 08.10.2018

Through the study of noble gases' binding with a macrocyclic receptor in water, it's revealed that differential cavitation energies drive host-guest binding, shedding light on gas-storage materials and biological receptors.

S. Sinn, F. Biedermann, Chemical Sensors based on Cucurbit[n]uril Macrocycles, Isr. J. Chem. 2018, 58, 357. 30.01.2018

This review article presents an in-depth examination of cucurbit[n]urils (CBn), emphasizing their high affinity for biologically relevant analytes and their potential in creating robust chemosensors for bio-monitoring and imaging applications.

F. Biedermann, L. De Cola, Porous supramolecular materials: The importance of emptiness, Supramol. Chem. 2018, 30, 166. 23.01.2018

This essay provides an opinion piece on the role of 'emptiness' in molecular systems. Investigations on hydrogels, metal-organic frameworks, and molecular hosts unveil novel perspectives on molecular recognition and porous materials'...

S. Sinn, L. Yang, F. Biedermann, D. Wang, C. Kübel, J. J. L. M. Cornelissen, L. De Cola, Templated Formation of Luminescent Virus-like Particles by Tailor-Made Pt(II) Amphiphiles, J. Am. Chem. Soc. 2018, 140, 2355. 22.01.2018

The creation of virus-like particles (VLPs) using luminescent Pt(II) complex amphiphiles demonstrates the potential of custom supramolecular systems in controlling the assembly of biological structures.

E. A. Appel, F. Biedermann, D. Hoogland, J. del Barrio, M. D. Driscoll, S. Hay, D. J. Wales, O. A. Scherman, Decoupled Associative and Dissociative Processes in Strong yet Highly Dynamic Host-Guest Complexes, J. Am. Chem. Soc. 2017, 139, 12985. 29.06.2017

This research provides a detailed investigation into the binding dynamics of various polymeric guests that form ternary complexes with cucurbit[8]uril, demonstrating the flexibility in designing host-guest systems for a broad range of applications.

F. Biedermann, Aqueous Self-Assembly; Comprehensive Supramolecular Chemistry 2nd Edition, Vol. 1 (Ed.: J. L. Atwood), Elsevier, Oxford, 2017, pp. 241–268. 29.06.2017

In this review, a thorough dissection of supramolecular assemblies in aqueous contexts is conducted, discussing a broad spectrum of self-assembling components and design strategies.

S. Sinn, F. Biedermann, L. De Cola, Platinum Complex Assemblies as Luminescent Probes and Tags for Drugs and Toxins in Water, Chem. Eur. J. 2017, 23, 1965. 01.12.2016

The development of a reactive phosphorescent Pt-based probe led to an emission-switch-on chemosensor capable of differentiating aza-heterocyclic drugs and toxins in water.

A. I. Lazar, F. Biedermann, K. R. Mustafina, K. I. Assaf, A. Hennig, W. M. Nau, Nanomolar Binding of Steroids to Cucurbit[n]urils: Selectivity and Applications, J. Am. Chem. Soc. 2016, 138, 13022. 22.09.2016

The use of Cucurbit[n]urils (CBn) as artificial receptors for steroids has been explored, revealing remarkable binding affinities and selectivities. This opens opportunities for enhanced drug delivery, enzyme assays, and differential sensing.

F. Biedermann, H.-J. Schneider, Experimental Binding Energies in Supramolecular Complexes, Chem. Rev. 2016, 116, 5216. 03.05.2016

A comprehensive examination of the binding strength in noncovalent supramolecular systems is provided, comparing various measurement strategies and their merits and limitations, as well as systematically exploring the different interaction types.

S. Sinn, F. Biedermann, M. Vishe, A. Aliprandi, C. Besnard, J. Lacour, L. De Cola, A ratiometric luminescent switch based on platinum complexes tethered to a crown‐ether scaffold, ChemPhysChem. 2016, 17, 1829. 25.02.2016

A ratiometric chemosensor for potassium, employing phosphorescent dinuclear cyclometalated PtII complexes, has been designed. Notable emission changes upon cation binding indicate potential for ratiometric sensing applications.